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«Directorate for Trade and Agriculture This report, which has been written by an outside consultant, is available only in its original language. It ...»

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Lemus, J.A., Blanco, G., Arroyo, B., Martinez, F., Grande, J. (2009), Fatal embryo chondral damage associated with fluoroquinolones in eggs of threatened avian scavengers. Environ. Pollut. 157(8Li, P.C.H., Swanson, E.J. and Gobas, F.A.P.C. (2002), Diazinon and its degradation products in agricultural water courses in British Columbia, Canada, Bull. Environ. Contam. Tox., 69, 59-65.

Li, D., Lyon, D.Y., Li, Q., Alvarez P.J.J. (2009), Effect of soil sorption and aquatic natural organic matter on the antibacterial activity of a fullerene water suspension. Environmental Toxicology and Chemistry 27(9): 1888-1894.

Loke ML, Ingerslev F, Halling-Sorensen B, Tjornelund J (2000), Stability of tylosin A in manure containing test systems determined by high performance liquid chromatography. Chemosphere 40:759-765 Lovern, S.B., Klaper, R. (2006), Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles. Environ. Toxicol. Chem. 25(4): 1132-1137.

Lovern, S.B., Strickler, J.R., Klaper, R. (2007), Behavioral and physiological changes in Daphnia magna when exposed to nanoparticle suspensions (titanium dioxide, nano C-60, and C(60)HxC(70)Hx). Environ. Sci. Technol. 41(12): 4465-4470.

Lubick N (2006), Still life with nanoparticles. Environ. Sci. Technol., 40(14): 4328.

Lyon, D.Y., Adams, L.K., Falkner, J.C., Alvareez, P.J.J. (2006), Antibacterial activity of fullerene

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Lyons, K., Scrimis, G. (2009), Under the Regulatory Radar? Nanotechnologies and their Impacts for Rural Australia. In Merlan F and Raftery D (Eds) Tracking Rural Change: Community, Policy and Technology in Australia, New Zealand and Europe. Australian National University E Press, Canberra, pp.151-171.

Mackay, C.E., Johns, M., Salatas, J.H., Bessinger, B., Perri, M. (2006), Stochastic probability modelling to predict the environmental stability of nanoparticles in aqueous suspension. Integr.

Environ. Assess. Manag. 2(3): 293-298.

Markandya, A., Taylor, T., Longo, A., Murty, M.N., Murty, S., Dhavala, K. (2008), Counting the cost of vulture decline - An appraisal of the human health and other benefits of vultures in India.

Ecological Economics 67(2): 194-204.

Migliore, L., Cozzolino, S., Fiori, M. (2003), Phytotoxicity to and uptake of enrofloxacin in crop plants. Chemosphere 52(7): 1233-1244.

Monteiro, S.C., Boxall, A.B.A. (2009), Factors affecting the degradation of pharmaceuticals in agricultural soils. Environmental Toxicology and Chemistry 28(12), 2009, 2546-2554.

Nagy NM, Konya J, Beszeda M, Beszeda I, Kalman E, Keresztes Z, Papp K, Cserny I (2003), Physical and chemical formations of lead contaminants in clay and sediment. J. Colloid Interf. Sci., 263(1): 13-22.

Oaks, J.L., Gilbert, M., Virani, M.Z., Watson, R.T., Meteyer, C.U., Rideout, B.A., Shivaprasad, H.L., Ahmed, S., Chaudhry, M.J.I., Arshad, M., Mahmood, S., Ali, A., Khan, A.A. (2004), Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427: 630-633.

Oberdorster E (2004), Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ. Health Persp., 112(10): 1058-1062.

Oberdorster E, Zhu S, Blickley TM, McClellan Green P, Haasch ML (2006), Ecotoxicology of carbon-based engineered nanoparticles: effect of fullerene (C60) on aquatic organisms. Carbon 44: 1112-1120.

Osano, O., Admiraal, W. and Otieno, D. (2002b), Developmental disorders in embryos of the frog Xenopus laevis induced by chloroacetanilide herbicides and their degradation products, Environ. Toxicol. Chem., 21, 375-379.

Osano, O., Admiraal, W., Klamer, H.J.C., Pastor, D. and Bleeker, E.A. (2002a), Comparative toxic and genotoxic effects of chloroacetanilides, formamidines and their degradation products on Vibrio fischeri and Chironomus riparius, Environ. Pollut., 119, 195-202.

Panter, G.H., Thompson, R.S., Sumpter, J.P. (1998), Adverse reproductive effects in male fathead minnows (Pimephales promelas) exposed to environmentally relevant concentrations of the natural oestrogens, oestradiol and oestrone. Aquat. Toxicol. 42(4): 243-253.

Panter, G.H., Thompson, R.S., Sumpter, J.P. (2000), Intermittent exposure of fish to estradiol.

Environ. Sci. Technol. 34(13) :2756-2760.

Pascoe, D., Karntanut, W., Mueller, C.T. (2003), Do pharmaceuticals affect freshwater invertebrates?

A study with the cnidarian Hydra vulgaris. Chemosphere 51: 521-528.

Phenrat T, Saleh N, Sirk K, Tilton RD, Lowry GV (2007), Aggregation and sedimentation of aqueous nanoscale zerovalent iron dispersions. Environ. Sci. Technol., 41: 284-290.

Pomati, F., Netting, A.G., Calamari, D., Neilan, B.A. (2004), Effects of erythromycin and ibuprofen on the growth of Synechocystis sp. and Lemna minor. Aquat. Toxicol. 67: 387-396.

Pope, L., Boxall, A., Corsing, C., Halling-Sorensen, B., Tait, A., Topp, E. (2009), Exposure assessment of veterinary medicines in terrestrial systems. In Crane M., Boxall, A.B.A., Barrett, K (Eds) Veterinary Medicines in the Environment. CRC Press, Boca Raton pp129-153 Ramirez, A.J., Brain, R.A., Usenko, S., Mottaleb, M.A., O'Donnell, J.G., Stahl, L.L., Wathen, J.B., Snyder, B.D., Pitt, J.L., Perez-Hurtado, P., Dobbins, L.L., Brooks, B.W., Chambliss, C.K.

(2009), Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States. Environ. Toxicol. Chem. 28(12): 2587-2597.

Redshaw, C.H., Wootton V.G., Rowland, S.J. (2008), Uptake of the pharmaceutical Fluoxetine Hydrochloride from growth medium by Brassicaceae. Phytochemistry 69(13): 2510-2516.

Roberts, A.P., Mount, A.S., Seda, B., Souther, J., Qiao, R., Lin, S., Chun Ke, P., Rao, A.P., Klaine, S.J. (2007), In-vivo biomodification of lipid-coated nanotubes by Daphnia magna. Environ. Sci.

Technol. 41: 3025-3029.

Roberts, T. (1998), Metabolic Pathways of Agrochemicals, Part One: Herbicides and Plant Growth Regulators, The Royal Society of Chemistry, Cambridge, UK.

Roberts, T. and Hutson, D. (1999), Metabolic Pathways of Agrochemicals, Part Two: Insecticides and Fungicides, The Royal Society of Chemistry, Cambridge, UK.

Rogers, NJ, Franklin, NM, Apte, SC, Batley, GE (2007), The importance of physical and chemical characterization in nanoparticle toxicity studies. Integr.Environ. Assess Manag., 3(2): 303-304.

Sanderson H., Johnson, D.I., Reitsma, T., Brain, R.A., Wilson, C.J., Solomon, K.R. (2003), Ranking and prioritisation of environmental risks of pharmaceuticals in surface waters. Regul. Toxicol.

Pharm., 39: 158-183.

Sanderson, H., Laird, B., Pope, L., Brain, R., Wilson, C., Johnson, D., Peregrine A., Bryning, G., Boxall A., Solomon, K. Assessment of the environmental fate and effects of ivermectin in aquatic mesocosms. Aquatic Toxicology, 85, 2007, 229-240.

Savage N, Diallo MS (2005), Nanomaterials and water purification: opportunities and challenges. J.

Nanoparticle Res. 7(4-5): 331-342.

SCENIHR (2007), Opinion on the appropriateness of the risk assessment methodology in accordance with the technical guidance documents for new and existing substances for assessing the risks of nanomaterials. EC Health and Consumer Protection DG.

Schallenberg, M., Armstrong, A. (2004), Assessment of antibiotic activity in surface water of the lower Taieri Plain and impacts on aquatic bacteria in Lake Waipori, South Otago, New Zealand.

New Zealand Journal of Marine and Freshwater Research 38(1): 19-28.

Schnoebelen, D.J., Kalkhoff, S.J., Becher, K.D. (2001), Occurrence and distribution of pesticides in streams of the Eastern Iowa basins 1996-1998. USGS Report, Iowa, USA Schwab, B.W., Hayes, E.P., Fiori, J.M. Mastrocco, F.J., Roden, N.M., Cragin, D., Meyerhoff, R.D., D'Aco, V.J., Anderson, P.D. (2005) Human pharmaceuticals in US surface waters: A human health risk assessment. Regulatory Toxicol. Pharmacol. 42(3): 296-312.

Sengelov, G., Agerso, Y., Halling Sorensen, B., Baloda, S.B., Andersen, J.S., Jensen, L.B. (2003), Bacterial antibiotic resistance levels in Danish farmland as a result of treatment with pig manure slurry. Environ. Int., 28: 587-595.

Sinclair C.J. and Boxall, A.B.A. (2003), Assessing the ecotoxicity of pesticide transformation products, Environ. Sci. Technol., 37, 4617-4625.

Sinclair, C.J., Boxall, A.B.A., Parsons, S.A., Thomas, M. (2006), Prioritization of pesticide environmental transformation products in drinking water supplies. Environ. Sci. Technol.

40(23): 7283-7289.

Smith, C.J., Shaw, B.J., Handy, R.D. (2007), Toxicity of single walled carbon nanotubes to rainbow trout (Oncorhyncus mykiss): respiratory toxicity, organ pathologies and other physiological effects. Aquat. Toxicol., 82: 94-109.

Sommer, C., Bibby, B.M. (2002), The influence of veterinary medicines on the decomposition of dung organic matter in soil. Eur J. Soil Biol. 38: 155-159.

Sondi, I., Salopek-Sondi, B. (2004), Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for gram-negative bacteria. J. Colloid Interf. Sci. 275(1): 177-182.

Stone V, Fernandes T.F., Ford A., Cristofi N. (2006), Suggested strategies for the ecotoxicological testing of new nanomaterials. Symposium Proceedings. Materials Research Society, Sym Proc.


Stoob K, Singer, HP, Mueller SR, Schwarzenbach RP, Stamm CH (2007), Dissipation and transport of veterinary sulphonamide antibiotics after manure application to grassland in a small catchment.

Environ Sci Technol 41:7349-7355 Templeton, R.C., Ferguson, P.L., Washburn, K.M., Scrivens, W.A., Chandler, G.T. (2006), Life-cycle effects of single-walled carbon nanotubes (SWNTs) on an estuarine meiobenthic copepod.

Environ. Sci. Technol. 40: 7387-7393.

ter Laak, T.L., Gebbink, W.A., Tolls, J. (2006), The effect of pH and ionic strength on the sorption of sulfachloropyridazine, tylosin, and oxytetracycline to soil. Environ. Toxicol. Chem. 25(4): 904ter Laak, T.L., Gebbink, W.A., Tolls, J. (2006), Estimation of soil sorption coefficients of veterinary pharmaceuticals from soil properties. Environ. Toxicol. Chem. 25(4): 933-941.

Ternes, T.A. (2001), Analytical methods for the determination of pharmaceuticals in aqueous environmental samples. Trends Analyt Chem. 20(8): 419-434.

Thomas, K.V., Hilton, M.J. (2004), The occurrence of selected human pharmaceutical compounds in UK estuaries. Mar. Pollut. Bull. 49(5-6): 436-444.

Thiele-Bruhn, S., Aust, M.O. (2004), Effects of pig slurry on the sorption of sulfonamide antibiotics in soil. Archives Environ Contam Toxicol 47(1): 31-39.

Tiede, K., Boxall, A.B.A., Tear, S.P., Lewis, J., David, H., Hassellov, M. (2008), Detection and characterisation of engineered nanoparticles in food and the environment. Food Addit. Contam..

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Tiede, K., Hassellov, M., Breitbarth, E., Chaudhry, Q., Boxall, A.B.A. (In press) Considerations for environmental fate and ecotoxicity testing to support environmental risk assessment for engineered nanoparticles. J. Chromatogr. A.

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Topp, E., Hendel, J.G., Lapen, D.R., Chapman, R. (2008b) Fate of the non-steroidal anti-inflammatory drug naproxen in agricultural soil receiving liquid municipal biosolids. Environ. Toxicol. Chem.

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Tong, Z., Bischoff, M., Nies, L., Applegate, B., Turco, R.F. (2007), Impact of fullerene (C60) on a soil microbial community. Environ. Sci. Technol. 41: 2985-2991.

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